Protective effect of exogenous administration of alpha-tocopherol in middle cerebral artery occlusion model of cerebral ischemia in rats.

@article{Chaudhary2003ProtectiveEO,
  title={Protective effect of exogenous administration of alpha-tocopherol in middle cerebral artery occlusion model of cerebral ischemia in rats.},
  author={Geeta Chaudhary and Kusum Sinha and Yogendra Kumar Gupta},
  journal={Fundamental & clinical pharmacology},
  year={2003},
  volume={17 6},
  pages={703-7}
}
Oxidative stress due to increased free radical generation and depletion of endogenous antioxidants have been implicated in ischemia-reperfusion-induced neuronal injury. The present study was carried out to study the effect of acute administration of alpha-tocopherol in the middle cerebral artery (MCA) occlusion model of stroke in rats. Rats were anesthetized using chloral hydrate (400 mg/kg i.p.) and subjected to 2 h of transient MCA occlusion. alpha-Tocopherol was administered at the dose of… CONTINUE READING

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