Protective effect of erythropoietin on renal ischemia and reperfusion injury.

  title={Protective effect of erythropoietin on renal ischemia and reperfusion injury.},
  author={Ersin Ateş and Ahmet Uğur Yalçin and Sezgin Y{\`i}lmaz and Tulay Koken and Çiğdem Tokyol},
  journal={ANZ journal of surgery},
  volume={75 12},
BACKGROUND Multiple protective effects of erythropoietin (EPO), such as antiapoptotic, antioxidant, angiogenic and neuroprotective effects, against ischemia have been demonstrated in cell culture and animal models. Genistein is also a potent tyrosine kinase inhibitor. The aims of the present study were to evaluate the effects of EPO on renal ischemia/reperfusion injury and to determine the role of the tyrosine kinase pathway on this process. METHODS Sprague-Dawley rats were assigned to five… CONTINUE READING
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