Protective effect of dopamine D2 agonists in cortical neurons via the phosphatidylinositol 3 kinase cascade.

@article{Kihara2002ProtectiveEO,
  title={Protective effect of dopamine D2 agonists in cortical neurons via the phosphatidylinositol 3 kinase cascade.},
  author={Takeshi Kihara and Shun Shimohama and Hideyuki Sawada and Kazuhiro Honda and Tomoki Nakamizo and Rie Kanki and Hiroshi Yamashita and Akinori Akaike},
  journal={Journal of neuroscience research},
  year={2002},
  volume={70 3},
  pages={274-82}
}
Glutamate, one of the excitatory neurotransmitters, contributes to the neuronal death associated with neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, and with ischemia. In Alzheimer's disease brains, there is a decreased number of dopamine D2 receptors, which might cause neuronal dysfunction or death. In the present study, bromocriptine exerted a protective effect against glutamate-induced cytotoxicity in rat cortical neurons. This neuroprotective effect was… CONTINUE READING
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