Protective effect of diphenyl diselenide on acute liver damage induced by 2-nitropropane in rats.

@article{Borges2005ProtectiveEO,
  title={Protective effect of diphenyl diselenide on acute liver damage induced by 2-nitropropane in rats.},
  author={Lysandro Pinto Borges and Vanessa Corralo Borges and Ang{\'e}lica Venturini Moro and Cristina Wayne Nogueira and Jo{\~a}o B T Rocha and Gilson Zeni},
  journal={Toxicology},
  year={2005},
  volume={210 1},
  pages={
          1-8
        }
}
The effect of diphenyl diselenide, (PhSe)2, administration on 2-nitropropane (2-NP)-induced hepatic damage was examined in male rats. Rats were pre-treated with a single dose of diphenyl diselenide (10, 50 or 100 micromol/kg). Afterward, they received only one dose of 2-NP (100 mg/kg body weight dissolved in olive oil). The parameters that indicate tissue damage such as plasma alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma-glutamyl transferase (GGT), alpha-fetoprotein… CONTINUE READING
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