Protective effect of deferoxamine on chromium(VI)-induced DNA single-strand breaks, cytotoxicity, and lipid peroxidation in primary cultures of rat hepatocytes

Abstract

Incubation of primary cultures of rat hepatocytes with K2Cr2O7 and deferoxamine (DFO), an iron chelator, resulted in a marked decrease in cellular levels of DNA single-strand breaks caused by K2Cr2O7. Cellular treatment with DFO also suppressed both dichromate-induced cytotoxicity – evaluated by the leakage of lactate dehydrogenase, and lipid peroxidation… (More)
DOI: 10.1007/s002040050397

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