Protective effect of daidzin against D-galactosamine and lipopolysaccharide-induced hepatic failure in mice.

@article{Kim2009ProtectiveEO,
  title={Protective effect of daidzin against D-galactosamine and lipopolysaccharide-induced hepatic failure in mice.},
  author={Sung-Hwa Kim and Jeong-Haing Heo and Yeong Shik Kim and Sam Sik Kang and Jae Sue Choi and Sun-Mee Lee},
  journal={Phytotherapy research : PTR},
  year={2009},
  volume={23 5},
  pages={701-6}
}
This study examined the effects of daidzin, a major isoflavone from Puerariae Radix, on D-galactosamine (D-GalN) and lipopolysaccharide (LPS)-induced liver failure. Mice were given an intraperitoneal injection of daidzin (25, 50, 100 and 200 mg/kg) 1 h before receiving an injection of D-GalN (700 mg/kg)/LPS (10 microg/kg). Daidzin markedly reduced the elevated serum aminotransferase activity and the levels of lipid peroxidation and tumor necrosis factor-alpha. The glutathione content was lower… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-7 of 7 extracted citations

Similar Papers

Loading similar papers…