Protective effect of colostrinin on neuroblastoma cell survival is due to reduced aggregation of β-amyloid

@article{Schuster2005ProtectiveEO,
  title={Protective effect of colostrinin on neuroblastoma cell survival is due to reduced aggregation of β-amyloid},
  author={David Schuster and Anitha Rajendran and Sek Wen Hui and Thomas M. Nicotera and Marian L. Kruzel},
  journal={Neuropeptides},
  year={2005},
  volume={39},
  pages={419-426}
}
Colostrinin (CLN), a mixture of proline-rich polypeptides, has shown a stabilizing effect on cognitive function in Alzheimer's patients measured by the Alzheimer's disease Assessment Scale-cognitive (ADAS-cog) and in Instrumental Activities of Daily Living (ILDL) in recently conducted clinical trials. The aim of this study was to elucidate a possible mode of action of CLN in the treatment of Alzheimer's disease. Here, we report that CLN prevents the aggregation of beta-amyloid peptide Abeta (1… CONTINUE READING

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