Protective effect of carnosine on adriamycin-induced oxidative heart damage in rats.

  title={Protective effect of carnosine on adriamycin-induced oxidative heart damage in rats.},
  author={Kalender Ozdoğan and Eylem Taskin and Nurcan Dursun},
  journal={Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology},
  volume={11 1},
  • K. OzdoğanE. TaskinN. Dursun
  • Published 1 February 2011
  • Medicine, Biology
  • Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology
OBJECTIVE Oxidative stress is one of the major factors involved in the pathogenesis of adriamycin (ADR)-induced cardiac dysfunction. The present study examined the antioxidant protective effects of carnosine (CAR) on adriamycin-induced cardiac damage in rats. METHODS Female Sprague Dawley rats were divided into four groups. Control (CONT, n=8, saline only i.v.); carnosine (CAR, n=8.10 mg/kg/day, i.v.); adriamycin (ADR, n=10.4 mg/kg four times every 2 days for 8 days, i.v.) alone and carnosine… 

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