Protective effect of caffeine against neurodegeneration in a model of Parkinson's disease in rat: behavioral and histochemical evidence.

@article{Joghataie2004ProtectiveEO,
  title={Protective effect of caffeine against neurodegeneration in a model of Parkinson's disease in rat: behavioral and histochemical evidence.},
  author={Mohammad Taghi Joghataie and Mehrdad Roghani and Fereidoun Negahdar and Leila Hashemi},
  journal={Parkinsonism & related disorders},
  year={2004},
  volume={10 8},
  pages={465-8}
}
Epidemiological studies have consistently demonstrated an inverse association between coffee consumption and Parkinson's disease (PD). This study was designed to investigate the beneficial effect of caffeine at a dose comparable to that of human exposure in a model of PD. For this purpose, unilateral intrastriatal 6-hydroxydopamine (6-OHDA)-lesioned rats were pretreated with caffeine (20 mg/kg; i.p.) 1 h before surgery and treated twice a day (10 mg/kg) for 1 month. Apomorphine-induced… CONTINUE READING
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