Protective effect of caffeic acid phenethyl ester (CAPE) administration on cisplatin-induced oxidative damage to liver in rat.

@article{Iraz2006ProtectiveEO,
  title={Protective effect of caffeic acid phenethyl ester (CAPE) administration on cisplatin-induced oxidative damage to liver in rat.},
  author={Mustafa Iraz and Elif Ozerol and Mukaddes Gulec and Seda Tasdemir and Nuri Idiz and Ersin Fadillioğlu and Mustafa Naziroǧlu and Omer Akyol},
  journal={Cell biochemistry and function},
  year={2006},
  volume={24 4},
  pages={357-61}
}
Cisplatin is one of the most active cytotoxic agents in the treatment of cancer. High doses of cisplatin have also been known to produce hepatotoxicity. Several studies suggest that supplementation with an antioxidant can influence cisplatin-induced hepatotoxicity. The present study was designed to determine the effects of cisplatin on the liver oxidant/antioxidant system, and the possible protective effects of caffeic acid phenethyl ester (CAPE) on liver toxicity induced by cisplatin. Twenty… CONTINUE READING
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