Protective effect of baicalein against endotoxic shock in rats in vivo and in vitro.

@article{Cheng2007ProtectiveEO,
  title={Protective effect of baicalein against endotoxic shock in rats in vivo and in vitro.},
  author={Pao-Yun Cheng and Yen-Mei Lee and Yuansheng Wu and Tz-Wei Chang and Jong-Shiaw Jin and Mao-Hsiung Yen},
  journal={Biochemical pharmacology},
  year={2007},
  volume={73 6},
  pages={
          793-804
        }
}
Dried roots of Scutellaria baicalensis Georgi (Huang qin) are widely used in traditional Chinese medicine. Baicalein is a major bioactive flavonoid component of H. qin that shows a wide range of biological activities, including antioxidant and anti-inflammatory actions. We evaluated therapeutic effects and possible mechanisms of action of baicalein on circulatory failure and vascular dysfunction during sepsis induced by lipopolysaccharide (LPS; 10 mg/kg, i.v.) in anesthetized rats. Treatment of… CONTINUE READING

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