Protective effect of atorvastatin in cultured osteoarthritic chondrocytes.

  title={Protective effect of atorvastatin in cultured osteoarthritic chondrocytes.},
  author={Theodora Simopoulou and Konstantinos N. Malizos and Lazaros A. Poultsides and Aspasia Tsezou},
  journal={Journal of orthopaedic research : official publication of the Orthopaedic Research Society},
  volume={28 1},
The aim of our study was to evaluate the in vitro effect of an HMG-CoA reductase inhibitor, atorvastatin, on the expression of significant anabolic and catabolic genes in human osteoarthritic chondrocytes and to explore the metabolic pathways involved in this process. Human articular osteoarthritic chondrocytes were cultured in the presence and absence of atorvastatin (10 and 50 micromol/L) for 24 h. Metalloproteinase 13 (MMP-13), collagen type II (COL2A1), and aggrecan (AGC) mRNA expression… CONTINUE READING