Protective effect of ascorbic acid in experimental gastric cancer: reduction of oxidative stress.

@article{Oliveira2003ProtectiveEO,
  title={Protective effect of ascorbic acid in experimental gastric cancer: reduction of oxidative stress.},
  author={Claudia Pinto Marques Souza de Oliveira and Paulo Kassab and F{\'a}bio Pinatel Lopasso and Heraldo Possolo de Souza and Mariano Janiszewski and Francisco Rafael Martins Laurindo and Kioshi Iriya and Ant{\^o}nio At{\'i}lio Laudanna},
  journal={World journal of gastroenterology},
  year={2003},
  volume={9 3},
  pages={446-8}
}
AIM Oxidative stress participates in the cell carcinogenesis by inducing DNA mutations. Our aim was to assess whether ascorbic acid, an antioxidant, could have a role in preventing ROS (Reactive Oxygen Species) generation in experimental gastric carcinoma in a rat model. METHODS Experimental gastric cancer was induced in twelve Wistar male rats (weighting 250-350 g) by profound duodeno-gastric reflux throught split gastrojenunostomy. The rats were allocated to the following groups: Group I (n… CONTINUE READING