Protective effect of apolipoprotein E against ischemic neuronal injury is mediated through antioxidant action.

@article{Kitagawa2002ProtectiveEO,
  title={Protective effect of apolipoprotein E against ischemic neuronal injury is mediated through antioxidant action.},
  author={Kazuo Kitagawa and Masayasu Matsumoto and Keisuke Kuwabara and Ken-ichiro Takasawa and Shigeru Tanaka and Tsutomu Sasaki and Kohji Matsushita and Toshiho Ohtsuki and Takehiko Yanagihara and Masatsugu Hori},
  journal={Journal of neuroscience research},
  year={2002},
  volume={68 2},
  pages={226-32}
}
Recent studies have demonstrated that apolipoprotein E (APOE) deficiency worsened neuronal injuries after transient focal and global cerebral ischemia. However, the molecular mechanism underlying the protective effect of APOE remains uncertain, even though several mechanisms, including excitotoxicty, free radicals, and apoptosis, have been cited as causes of selective neuronal vulnerability in cerebral ischemia. In the present study, we first compared the vulnerability of cultured neurons… CONTINUE READING

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