Protective effect of a selective leukotriene antagonist in endotoxemia in the rat.

@article{Cook1985ProtectiveEO,
  title={Protective effect of a selective leukotriene antagonist in endotoxemia in the rat.},
  author={James A. Cook and W. C. Wise and Perry V. Halushka},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1985},
  volume={235 2},
  pages={470-4}
}
The role of lipoxygenase metabolites as inflammatory mediators in endotoxic shock remains uncertain. In the present study, the effects of a selective leukotriene (LT) D4/LTE4 antagonist, LY171883, 1-[2-hydroxy-3-propyl-4-[4-(1H-tetrazol-5-YL)-butoxy]-phenyl ethanone], on endotoxin-induced sequelae in the rat were assessed. LY171883 was given as a bolus (30… CONTINUE READING