Protective effect of a naked DNA vaccine cocktail against lethal toxoplasmosis in mice.

@article{Fachado2003ProtectiveEO,
  title={Protective effect of a naked DNA vaccine cocktail against lethal toxoplasmosis in mice.},
  author={Alberto Fachado and Alexandro Rodriguez and Sergio Oscar Angel and Diamar C Pinto and Iviane Vila and Armando Acosta and Regina R Amendoeira and Joseli Lannes-Vieira},
  journal={Vaccine},
  year={2003},
  volume={21 13-14},
  pages={
          1327-35
        }
}
BALB/c mice were intramuscularly immunized with low doses (25-50microg) of DNA cocktail containing plasmids encoding the full-length SAG1/P30 and the 196-561 terminal sequence of ROP2 genes. This immunization resulted in a Th1-type response with predominance of IgG2a and a specific T-cell proliferation with high levels of interferon-gamma (IFN-gamma) secretion, whereas no IL-4 was detected. Moreover, DNA cocktail immunization induced a long-lasting protection against a lethal challenge with the… CONTINUE READING
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