Protective effect of a gonadotropin-releasing hormone analogue on chemotherapeutic agent-induced ovarian gonadotoxicity: a mouse model.

@article{Tan2010ProtectiveEO,
  title={Protective effect of a gonadotropin-releasing hormone analogue on chemotherapeutic agent-induced ovarian gonadotoxicity: a mouse model.},
  author={S J Tan and Yu-Chi Yeh and Wei-Jen Shang and Gwo-Jang Wu and Jah-yao Liu and Chi-Huang Chen},
  journal={European journal of obstetrics, gynecology, and reproductive biology},
  year={2010},
  volume={149 2},
  pages={182-5}
}
OBJECTIVE To demonstrate the protective effect of triptorelin, a GnRH analogue, on chemotherapy-induced ovarian gonadotoxicity. STUDY DESIGN Twenty-four sexually mature, virgin, female FVB/NJNarl mice were divided into four groups: busulfan (B); low-dose triptorelin plus busulfan (T(L)+B); high-dose triptorelin plus busulfan (T(H)+B); and control. Mice in the T(L)+B and T(H)+B groups were injected with 3.8 and 38 mg/kg of triptorelin subcutaneously, respectively. Four weeks later, mice in the… CONTINUE READING