Protective effect of Tanshinone IIA on the early stage of experimental diabetic nephropathy.

@article{Kim2009ProtectiveEO,
  title={Protective effect of Tanshinone IIA on the early stage of experimental diabetic nephropathy.},
  author={Su Kang Kim and Kyung-Hee Jung and Byung-Cheol Lee},
  journal={Biological & pharmaceutical bulletin},
  year={2009},
  volume={32 2},
  pages={220-4}
}
Diabetic nephropathy (DN) has become the leading cause of end stage renal failure, and prevention or retardation of DN has become a major goal in biomedical research. In this study, Tanshinone IIA, a component extracted from Salvia miltiorrhiza, was studied in experimental rats in which DN was induced by streptozotocin (STZ) treatment. The DN rats were treated with 10 mg/kg of Tanshinone IIA for 12 weeks to analyze its reno-protective effect with different parameters. Renal hypertrophy and 24-h… CONTINUE READING
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