Protective effect of S12340 on cardiac cells exposed to oxidative stress.

@article{Iliou1993ProtectiveEO,
  title={Protective effect of S12340 on cardiac cells exposed to oxidative stress.},
  author={J. Iliou and C. Thollon and F. Robin and C. Cambarrat and C. Guillonneau and G. Regnier and A. Lenaers and J. P. Vilaine},
  journal={European journal of pharmacology},
  year={1993},
  volume={248 3},
  pages={
          263-72
        }
}
  • J. Iliou, C. Thollon, +5 authors J. P. Vilaine
  • Published 1993
  • Chemistry, Medicine
  • European journal of pharmacology
  • Oxidative stress induced by reactive oxygen species is one aspect of the deleterious mechanisms involved in myocardial post-ischemic reperfusion injury. The antioxidant properties of the new molecule S12340 (8-[3-(3,5-diterbutyl-4-hydroxyphenyl-thio)propyl]-1-oxa-2- oxo-3,8-diazaspiro[4.5]decane) were evaluated using three successive in vitro approaches mimicking the cardiac cell damages induced by reactive oxygen species released into the reperfused myocardium. (i) The effects of S12340 on… CONTINUE READING
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