Protective effect of PEGylation against poly(amidoamine) dendrimer-induced hemolysis of human red blood cells.

@article{Wang2010ProtectiveEO,
  title={Protective effect of PEGylation against poly(amidoamine) dendrimer-induced hemolysis of human red blood cells.},
  author={Wei Wang and Wei Xiong and Yanhong Zhu and Huibi Xu and Xiangliang Yang},
  journal={Journal of biomedical materials research. Part B, Applied biomaterials},
  year={2010},
  volume={93 1},
  pages={59-64}
}
Poly(amidoamine) (PAMAM) dendrimers are widely used in medical applications. However, dendrimers bearing positively charged surface groups are prone to destabilize cell membrane and cause cell lysis. The lytic effect of dendrimers on red blood cells (RBCs) namely hemolysis is extremely dangerous when administered in vivo. To diminish the hematologic toxicity, we modified PAMAM dendrimers with poly(ethylene glycol) (PEG) of three molecular weights (2k, 5k, and 20k). The protective effect of… CONTINUE READING

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