Protective effect of P188 in the model of acute trauma to human ankle cartilage: the mechanism of action.

@article{Bajaj2010ProtectiveEO,
  title={Protective effect of P188 in the model of acute trauma to human ankle cartilage: the mechanism of action.},
  author={Sarvottam Bajaj and T Shoemaker and Arnavaz A Hakimiyan and Lev Rappoport and Cecilia Pascual-Garrido and Theodore R. Oegema and Markus A Wimmer and Susan Chubinskaya},
  journal={Journal of orthopaedic trauma},
  year={2010},
  volume={24 9},
  pages={571-6}
}
OBJECTIVE Because P188 poloxamer is effective in promoting cell survival in models of acute trauma, the objectives were to understand the mechanism of its action focusing on glycogen synthase kinase-3 (GSK3) activation, interleukin-6 (IL-6), and p38 signaling. DESIGN Sixteen normal human tali were impacted using a 4-mm diameter indenter with an impulse of 1 Ns. Eight-millimeter cartilage plugs containing the 4-mm impacted core and 4-mm adjacent nonimpacted ring were removed and cultured with… CONTINUE READING
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