Protective effect of Nigella sativa oil against tramadol-induced tolerance and dependence in mice: role of nitric oxide and oxidative stress.

@article{AbdelZaher2011ProtectiveEO,
  title={Protective effect of Nigella sativa oil against tramadol-induced tolerance and dependence in mice: role of nitric oxide and oxidative stress.},
  author={Ahmed Osman Abdel-Zaher and Mahran Sh Abdel-Rahman and Fahmy M Elwasei},
  journal={Neurotoxicology},
  year={2011},
  volume={32 6},
  pages={725-33}
}
Nigella sativa seed extracts and its oil have been exploited for their various health benefits. In this study, the effects of N. sativa oil on tramadol-induced tolerance and dependence and possible mechanism(s) of these effects were investigated, for the first time, in mice. Repeated administration of N. sativa oil (4 ml/kg, p.o.) along with tramadol (50mg/kg, s.c.) inhibited the development of tramadol tolerance, as measured by the hot plate test, and dependence as assessed by naloxone (5mg/kg… CONTINUE READING