Protective effect of GTS-21, a novel nicotinic receptor agonist, on delayed neuronal death induced by ischemia in gerbils.

@article{Nanri1998ProtectiveEO,
  title={Protective effect of GTS-21, a novel nicotinic receptor agonist, on delayed neuronal death induced by ischemia in gerbils.},
  author={Masato Nanri and Jyunji Yamamoto and Hideaki Miyake and Hiroshi Watanabe},
  journal={Japanese journal of pharmacology},
  year={1998},
  volume={76 1},
  pages={23-9}
}
The neuroprotective effects of GTS-21 [3-(2,4-dimethoxybenzylidene)-anabaseine dihydrochloride] were studied and compared with those of nicotine, 9-amino-1,2,3,4-tetrahydroacridine hydrochloride hydrate (THA) and pentobarbital-Na (PB) using a cerebral ischemia model in Mongolian gerbils. The learning performance and memory retention were elucidated by a step-through passive avoidance task at 2 and 3 days after ischemia-reperfusion. In this task, the ischemia-operated gerbils showed impairment… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 17 extracted citations

Nicotinic Acetylcholine Receptor Signaling in Neuroprotection

Nicotinic Acetylcholine
Springer Singapore • 2018

Outcomes associated with transdermal nicotine replacement therapy in a neurosurgery intensive care unit.

American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists • 2010
View 1 Excerpt

Similar Papers

Loading similar papers…