Corpus ID: 26190616

Protective effect and mechanism of Ginkgo biloba leaf extracts for Parkinson disease induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.

  title={Protective effect and mechanism of Ginkgo biloba leaf extracts for Parkinson disease induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.},
  author={S. F. Yang and Q. Wu and An-sheng Sun and X N Huang and J S Shi},
  journal={Acta pharmacologica Sinica},
  volume={22 12},
AIM To observe the effects of extracts of Ginkgo biloba leaves (EGb) on the Parkinson disease (PD) models induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and its ion 1-methyl-4-phenylpyridinium (MPP+). METHODS MPTP was microinjected into substantia nigra of rats to induce a behavior change of rotation. EGb (ip, 50 or 100 . d-1) was pretreated consecutively for 19 d before MPTP administered and 1 d after MPTP administered. The contents of malondialdehyde (MDA… Expand
The effect of Ginkgo biloba extract on 3-nitropropionic acid-induced neurotoxicity in rats
Results suggest that EGb 761 has a neuroprotective role in the current HD paradigm, which may be related to improvement of energy metabolism, antioxidant properties and antiapoptotic effects. Expand
Effect of a phytopharmaceutical medicine, Ginko biloba extract 761, in an animal model of Parkinson's disease: therapeutic perspectives.
It has been shown that EGb761 can provide a neuroprotective/neurorecovery effect against the damage to midbrain DA neurons in an animal model of PD, and studies suggest it as an alternative in the future treatment of PD. Expand
The protective effect of hyperbaric oxygen and Ginkgo biloba extract on Aβ25–35-induced oxidative stress and neuronal apoptosis in rats
It is suggested that HBO and EGB761 reduce cell toxicity and oxidative stress by blocking mitochondria-mediated apoptosis signaling in AD, and the combined treatment of HBO and Ginkgo further enhances these effects. Expand
Protective Effect of Ginkgo Biloba Extract and Pumpkin Seed Oil Against Neurotoxicity of Rotenone in Adult Male Rats
The principal goal of the current work was to investigate the protective effect of Ginkgo biloba extract an d pumpkin s eed oil in separate against ro tenone induced neurotoxicity in m ale rats.Expand
EGb761 protects against nigrostriatal dopaminergic neurotoxicity in 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine‐induced Parkinsonism in mice: role of oxidative stress
The findings suggest that, in mice, EGb761 attenuates MPTP‐induced neurodegeneration of the nigrostriatal pathway and that an inhibitory effect against oxidative stress may be partly responsible for its observed neuroprotective effects. Expand
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Protective effects of Ginkgo biloba extract on paraquat-induced apoptosis of PC12 cells.
The results showed that after incubation of PC12 cells with EGb761 prior to PQ exposure, the PQ-induced decrease of cell viability was significantly reversed, the collapse of mitochondrial membrane potential (MMP) was attenuated and the percentage of apoptotic cells was reduced. Expand
Effect of fraxetin and myricetin on rotenone-induced cytotoxicity in SH-SY5Y cells: comparison with N-acetylcysteine.
It is suggested that fraxetin can reduce apoptosis, possibly by decreasing free radical generation in SH-SY5Y cells, and the possible signal pathway involved in a neuronal cell model of Parkinson's disease is investigated. Expand
Melatonin attenuates 1-methyl-4-phenylpyridinium-induced PC12 cell death
Melatonin attenuated PC12 cell death induced by 1-methyl-4-phenylpyridinium and abolished the LDH leakage of cells treated with MPP+ and increased TH+ cells count, and the level of glucose was an important factor toMPP+ induced dopaminergic PC 12 cell death. Expand
Myricetin, a naturally occurring flavonoid, prevents 2-deoxy-D-ribose induced dysfunction and oxidative damage in osteoblastic MC3T3-E1 cells.
It is demonstrated that myricetin attenuates 2-deoxy-d-ribose induced damage, suggesting that myicetin may be a useful dietary supplement for minimizing oxidative injury in diabetes related bone diseases. Expand