Protective drugs in acute large-dose exposure to organophosphates: a comparison of metoclopramide and tiapride with pralidoxime in rats.

@article{Petroianu2005ProtectiveDI,
  title={Protective drugs in acute large-dose exposure to organophosphates: a comparison of metoclopramide and tiapride with pralidoxime in rats.},
  author={Georg A Petroianu and Mohammed Y. Hasan and Syed Muhammad Nurulain and Kholoud Arafat and R. R.-B. Sheen and Ayman Saleh and Andrea Schmitt},
  journal={Anesthesia and analgesia},
  year={2005},
  volume={100 2},
  pages={382-6}
}
Weak and reversible inhibitors of cholinesterase(s), when coadministered in excess with a more potent inhibitor such as organophosphates, can act in a protective manner. The benzamide compound, metoclopramide, confers some protection (putatively via this mechanism) for cholinesterases against inhibition by paraoxon both in vitro and in vivo, after chronic small-dose exposure. Tiapride is a related benzamide. In this study, we compared the protection by metoclopramide and tiapride in rats… CONTINUE READING
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