Protective axis of the renin-angiotensin system in the brain.

  title={Protective axis of the renin-angiotensin system in the brain.},
  author={Mariela Mercedes Gironacci and Flavia M. Cerniello and Nadia A Longo Carbajosa and Jorge Goldstein and Bruno D Cerrato},
  journal={Clinical science},
  volume={127 5},
The RAS (renin-angiotensin system) is composed of two arms: the pressor arm containing AngII (angiotensin II)/ACE (angiotensin-converting enzyme)/AT1Rs (AngII type 1 receptors), and the depressor arm represented by Ang-(1-7) [angiotensin-(1-7)]/ACE2/Mas receptors. All of the components of the RAS are present in the brain. Within the brain, Ang-(1-7) contributes to the regulation of BP (blood pressure) by acting at regions that control cardiovascular function such that, when Ang-(1-7) is… CONTINUE READING


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