Protective antigens of Bordetella pertussis mouse-protection test against intracerebral and aerosol challenge of B. pertussis.

Pertussis toxin (PT) and filamentous hemagglutinin (FHA) which are the main components of pertussis vaccine in Japan, were investigated concerning their role as protective antigens. Four different experiments were carried out to investigate the ability of the antigens or antibodies to protect mice from pertussis infection: 1) Mice immunized with… CONTINUE READING