Protective antibodies develop, and murine Lyme arthritis regresses, in the absence of MHC class II and CD4+ T cells.

@article{Fikrig1997ProtectiveAD,
  title={Protective antibodies develop, and murine Lyme arthritis regresses, in the absence of MHC class II and CD4+ T cells.},
  author={Erol Fikrig and Stephen W. Barthold and Manchuan Chen and Cheong Hee Chang and Richard A Flavell},
  journal={Journal of immunology},
  year={1997},
  volume={159 11},
  pages={5682-6}
}
Murine Lyme borreliosis is characterized by arthritis and carditis that are most severe at 2 to 3 wk, then regress during the course of persistent infection. Borrelia burgdorferi-specific Abs and CD4+ T cells have been implicated in the resolution phase of arthritis. Therefore, MHC class II transactivator (CIITA)-deficient mice that do not express conventional class II molecules and lack the normal CD4 repertoire were used to investigate the role of MHC class II-mediated responses in Lyme… CONTINUE READING
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