Protective and toxic roles of dopamine in Parkinson's disease

@article{SeguraAguilar2014ProtectiveAT,
  title={Protective and toxic roles of dopamine in Parkinson's disease},
  author={J. Segura-Aguilar and I. Paris and Patricia Mu{\~n}oz and E. Ferrari and L. Zecca and F. Zucca},
  journal={Journal of Neurochemistry},
  year={2014},
  volume={129},
  pages={898 - 915}
}
The molecular mechanisms causing the loss of dopaminergic neurons containing neuromelanin in the substantia nigra and responsible for motor symptoms of Parkinson's disease are still unknown. The discovery of genes associated with Parkinson's disease (such as alpha synuclein (SNCA), E3 ubiquitin protein ligase (parkin), DJ‐1 (PARK7), ubiquitin carboxyl‐terminal hydrolase isozyme L1 (UCHL‐1), serine/threonine‐protein kinase (PINK‐1), leucine‐rich repeat kinase 2 (LRRK2), cation‐transporting… Expand
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