Protective and toxic effects of vitamin D on vascular calcification: clinical implications.

@article{Zittermann2008ProtectiveAT,
  title={Protective and toxic effects of vitamin D on vascular calcification: clinical implications.},
  author={Armin Zittermann and Reiner Koerfer},
  journal={Molecular aspects of medicine},
  year={2008},
  volume={29 6},
  pages={423-32}
}
The presence of vascular calcification (VC) is a predictor of poor survival in the general population. The development of VC is an active process that requires a pre-existing injury as an inducer and promoting factors such as hyperphosphatemia and hypercalcemia, as well as a deficiency in calcification repressor factors. Vascular smooth muscle cells possess an endogenous enzyme system for the biosynthesis of the vitamin D hormone calcitriol from its precursor 25-hydroxyvitamin D and also a… CONTINUE READING
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