Protective and regenerative effects of the GH/IGF-I axis on the brain.

  title={Protective and regenerative effects of the GH/IGF-I axis on the brain.},
  author={J{\"o}rgen Isgaard and David N. {\AA}berg and Maria Nilsson},
  journal={Minerva endocrinologica},
  volume={32 2},
Apart from regulating somatic growth and metabolism, evidence suggest that the GH/ IGF-I axis is involved in the regulation of brain growth, development and myelination. Moreover, growth hormone (GH) and particularly IGF-I have been attributed neuroprotective effects in different in vitro and in vivo experimental models. In addition, both GH and IGF-I affect cognition and biochemistry in the adult brain. Some of the effects of GH are suggested to be mediated by circulating IGF-I, while other… CONTINUE READING
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