Protective and pathogenic roles of CD8+ T cells during malaria infection.

@article{Hafalla2006ProtectiveAP,
  title={Protective and pathogenic roles of CD8+ T cells during malaria infection.},
  author={Julius C. R. Hafalla and Ian A. Cockburn and Fidel P. Zavala},
  journal={Parasite immunology},
  year={2006},
  volume={28 1-2},
  pages={15-24}
}
CD8+ T cells play a key role in protection against pre-erythrocytic stages of malaria infection. Many vaccine strategies are based on the idea of inducing a strong infection-blocking CD8+ T cell response. Here, we summarize what is known about the development, specificity and protective effect of malaria-specific CD8+ T cells and report on recent developments in the field. Although work in mouse models continues to make progress in our understanding of the basic biology of these cells, many… CONTINUE READING