Protective actions of administered mesenchymal stem cells in acute kidney injury: relevance to clinical trials

@inproceedings{Westenfelder2011ProtectiveAO,
  title={Protective actions of administered mesenchymal stem cells in acute kidney injury: relevance to clinical trials},
  author={Christof Westenfelder and Florian E Togel},
  booktitle={Kidney international supplements},
  year={2011}
}
Current therapies for acute kidney injury remain primarily supportive and have failed to reduce morbidity, mortality (>50%), and associated costs. This prompted our studies in which rats with bilateral ischemia/reperfusion-induced acute kidney injury were treated with bone marrow-derived, culture-expanded allogeneic mesenchymal stem cells. Their administration into the suprarenal aorta after reflow significantly protected renal function and hastened repair, mediated by complex antiapoptotic… CONTINUE READING
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