Protective Role of Ramipril and Candesartan against Myocardial Ischemic Reperfusion Injury: A Biochemical and Transmission Electron Microscopical Study

@article{SheikUduman2016ProtectiveRO,
  title={Protective Role of Ramipril and Candesartan against Myocardial Ischemic Reperfusion Injury: A Biochemical and Transmission Electron Microscopical Study},
  author={Mohamed Saleem Thattakudian Sheik Uduman and Rajitha Bodd Reddy and Priyanka Punuru and Gopinath Chakka and Gauthaman Karunakaran},
  journal={Advances in Pharmacological Sciences},
  year={2016},
  volume={2016}
}
The present study was designed to investigate the role of combined administration of Ramipril and Candesartan against in vitro myocardial ischemic reperfusion injury in rat. Male Wistar albino rats were divided into five groups (n = 6) and treated with saline (10 mL/kg), Ramipril (2 mg/kg), Candesartan (1 mg/kg), and the combination of both drugs, respectively 24 h before induction of global ischemia (5 min of stabilization, 9 min of global ischemia, and 12 min of reflow). Combination of… 

Figures and Tables from this paper

Protective Effect of Co Q10 and Candesartan on Bleomyycin Induced Lung Fibrosis in Rats
Fibrosis of the lungs is the final phase of many lung illnesses. Its characterized by excessive matrix production leading to the normal lung architecture destruction and eventually death. CoQ10 is an
Candesartan in a rat model of testicular toxicity: New insight on its protective mechanism
TLDR
Cisplatin-induced testicular toxicity was investigated and candesartan mitigated the gonadotoxicity induced by cisplatin via antioxidative, anti-inflammatory, and antiapoptotic actions.
Protective Effect of Co Q10 and Candesartan on Bleomyycin Induced Lung Fibrosis in Rats
AJPS (2021) 16 Protective Effect of Co Q10 and Candesartan on Bleomyycin Induced Lung Fibrosis in Rats Fatima Mohammad Saeed Mahdi *, Mustafa Ghazi Alabbassi **, Muthanna Ibrahim Al-Ezzi **.

References

SHOWING 1-10 OF 44 REFERENCES
Cardioprotection of ramipril and BQ-123 against myocardial ischemia/reperfusion oxidative injury in vivo in rats
TLDR
The protective effects of the combination on delaying onset ofVA, shortening duration of VA,decreasing infarct size and content of MDA, and increasing activity of SOD are better than those of using ramipril or BQ-123 alone.
Chronic garlic administration protects rat heart against oxidative stress induced by ischemic reperfusion injury
TLDR
The study strongly suggests that chronic garlic administration prevents oxidative stress and associated ultrastructural changes, induced by myocardial ischemic-reperfusion injury.
Captopril and ramiprilat protect against free radical injury in isolated working rat hearts.
  • X. Pi, X. Chen
  • Medicine, Chemistry
    Journal of molecular and cellular cardiology
  • 1989
Influence of ramiprilat and losartan on ischemia reperfusion injury in rat hearts
TLDR
The data indicate that losartan and ramiprilat protect the heart against ischemia/reperfusion injury independently of their hemodynamic effects but in a time-dependent manner.
Effect of Ramiprilat or Captopril on Myocardial Infarct Size: Assessment in Canine Models of Ischemia Alone and Ischemia with Reperfusion
TLDR
Neither captopril nor ramiprilat protected the heart from injury under conditions of ischemia with reperfusion or ischemies without reperfusions.
Effect of verapamil post-treatment in myocardial reperfusion injury.
TLDR
Verapamil post-treatment can prevent reperfusion-induced myocardial injury but functional recovery may be delayed due to the drug's inherent direct myocardia depressant effect.
The relationship between oxygen radical generation and impairment of myocardial energy metabolism following post-ischemic reperfusion.
Nitric Oxide Mechanism of Protection in Ischemia and Reperfusion Injury
TLDR
This paper will focus on the mechanistic actions of NO in ischemia and reperfusion injury, along with the compound's potential therapeutic benefits.
...
1
2
3
4
5
...