Protective Role of Ramipril and Candesartan against Myocardial Ischemic Reperfusion Injury: A Biochemical and Transmission Electron Microscopical Study

@article{SheikUduman2016ProtectiveRO,
  title={Protective Role of Ramipril and Candesartan against Myocardial Ischemic Reperfusion Injury: A Biochemical and Transmission Electron Microscopical Study},
  author={Mohamed Saleem Thattakudian Sheik Uduman and Rajitha Bodd Reddy and Priyanka Punuru and Gopinath Chakka and Gauthaman Karunakaran},
  journal={Advances in Pharmacological Sciences},
  year={2016},
  volume={2016}
}
The present study was designed to investigate the role of combined administration of Ramipril and Candesartan against in vitro myocardial ischemic reperfusion injury in rat. Male Wistar albino rats were divided into five groups (n = 6) and treated with saline (10 mL/kg), Ramipril (2 mg/kg), Candesartan (1 mg/kg), and the combination of both drugs, respectively 24 h before induction of global ischemia (5 min of stabilization, 9 min of global ischemia, and 12 min of reflow). Combination of… 
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