Protective Role of HO-1 for Alcohol-Dependent Liver Damage

@article{Nussler2010ProtectiveRO,
  title={Protective Role of HO-1 for Alcohol-Dependent Liver Damage},
  author={A. Nussler and L. Hao and D. Knobeloch and P. Yao and N. Nussler and Z. Wang and L. Liu and S. Ehnert},
  journal={Digestive Diseases},
  year={2010},
  volume={28},
  pages={792 - 798}
}
  • A. Nussler, L. Hao, +5 authors S. Ehnert
  • Published 2010
  • Medicine
  • Digestive Diseases
  • Background/Aims: Alcoholic liver disease is continuously increasing in developed countries being a leading cause of death worldwide. Chronic ethanol consumption induces oxidative stress by accumulation of reactive oxygen intermediates (ROI) while reducing the cellular antioxidant defense. Induction of heme oxygenase-1 (HO-1) may protect primary human hepatocytes (hHeps) from such damage. Thus, the aim of this study was to investigate the potential of polyphenols to protect hHeps from ethanol… CONTINUE READING

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