Protective Monoclonal Antibodies Define a Distinct, Conserved Epitope on an Apical Complex Exoantigen of Cryptosporidium parvum Sporozoites

@article{Riggs1996ProtectiveMA,
  title={Protective Monoclonal Antibodies Define a Distinct, Conserved Epitope on an Apical Complex Exoantigen of Cryptosporidium parvum Sporozoites},
  author={Michael W Riggs and P A Yount and Alice L. Stone and Rebecca C. Langer},
  journal={Journal of Eukaryotic Microbiology},
  year={1996},
  volume={43}
}
Role of CSL glycoprotein in infectivity and neutralization of Cryptosporidium parvum sporozoites
TLDR
It is reported that CSL has properties consistent with being a sporozoite ligand for epithelial cells, and has been found to have the greatest level of neutralizing activity against C. parvum infections. Expand
The immunology of parasite infections in immunocompromised hosts
TLDR
The burden and immunology of parasitic infections in patients who are immunocompromised secondary to congenital immunodeficiency, malnutrition, malignancy, and immunosuppressive medications is discussed. Expand
Characterization and Formulation of Multiple Epitope-Specific Neutralizing Monoclonal Antibodies for Passive Immunization against Cryptosporidiosis
TLDR
Findings indicate that polyvalent neutralizing MAb formulations targeting epitopes on defined antigens may provide optimal passive immunization against cryptosporidiosis. Expand
Cryptosporidium: molecular basis of host-parasite interaction.
TLDR
This chapter reviews the existing knowledge of the molecular basis of various host-parasite interactions and of specific molecules that may be involved in them, and identifies areas in which further investigation is necessary. Expand

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Hyperimmune bovine antibody prepared against C. parvum may provide a first-generation therapy for control of cryptosporidiosis, and the defined antigens can be evaluated as subunit immunogens to produce better-characterized polyclonal antibody for control. Expand
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TLDR
The results indicate that two different molecules capable of inducing neutralizing antibody are exposed on the surface of C. parvum sporozoites. Expand
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Publisher Summary This chapter discusses the distinction of epitopes by monoclonal antibodies. The chapter explains that hybridoma technology has become very efficient in the production of largeExpand
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The present study was undertaken to characterize the ultrastructural aspects of antibody-sporozoite interaction and found that antibodies neutralize sporozoites, and cause the formation of a thread-like precipitate on the parasites. Expand
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