Protective Monoclonal Antibodies Define a Distinct, Conserved Epitope on an Apical Complex Exoantigen of Cryptosporidium parvum Sporozoites

  title={Protective Monoclonal Antibodies Define a Distinct, Conserved Epitope on an Apical Complex Exoantigen of Cryptosporidium parvum Sporozoites},
  author={Michael W Riggs and P A Yount and Alice L. Stone and Rebecca C. Langer},
  journal={Journal of Eukaryotic Microbiology},
Role of CSL glycoprotein in infectivity and neutralization of Cryptosporidium parvum sporozoites
It is reported that CSL has properties consistent with being a sporozoite ligand for epithelial cells, and has been found to have the greatest level of neutralizing activity against C. parvum infections. Expand
The immunology of parasite infections in immunocompromised hosts
The burden and immunology of parasitic infections in patients who are immunocompromised secondary to congenital immunodeficiency, malnutrition, malignancy, and immunosuppressive medications is discussed. Expand
Characterization and Formulation of Multiple Epitope-Specific Neutralizing Monoclonal Antibodies for Passive Immunization against Cryptosporidiosis
Findings indicate that polyvalent neutralizing MAb formulations targeting epitopes on defined antigens may provide optimal passive immunization against cryptosporidiosis. Expand
Cryptosporidium: molecular basis of host-parasite interaction.
This chapter reviews the existing knowledge of the molecular basis of various host-parasite interactions and of specific molecules that may be involved in them, and identifies areas in which further investigation is necessary. Expand


Bovine antibody against Cryptosporidium parvum elicits a circumsporozoite precipitate-like reaction and has immunotherapeutic effect against persistent cryptosporidiosis in SCID mice
Hyperimmune bovine antibody prepared against C. parvum may provide a first-generation therapy for control of cryptosporidiosis, and the defined antigens can be evaluated as subunit immunogens to produce better-characterized polyclonal antibody for control. Expand
57:2283. 116359. bound 2,820 f 190 cpm
  • Infect. Immun
  • 1992
Neutralization-sensitive epitopes are conserved among geographically diverse isolates of Cryptosporidium parvum
Results indicate that two neutralization-sensitive epitopes are conserved on geographically diverse C. parvum isolates and are associated with sporozoite surface epitopes originally identified in an Iowa isolate. Expand
Effects of immune colostrum and orally administered antisporozoite monoclonal antibodies on the outcome of Cryptosporidium parvum infections in neonatal mice
A neonatal BALB/c mouse model of cryptosporidiosis was used to examine the potential passive transfer of immunity via immune colostrum and oral treatment with anticryptosporidial monoclonalExpand
Neutralization-sensitive epitopes are exposed on the surface of infectious Cryptosporidium parvum sporozoites.
The results indicate that two different molecules capable of inducing neutralizing antibody are exposed on the surface of C. parvum sporozoites. Expand
Monoclonal antibody identifies circumsporozoite protein of Plasmodium malariae and detects a common epitope on Plasmodium brasilianum sporozoites
A hybridoma secreting an immunoglobulin G1 monoclonal antibody against the circumsporozoite protein of the human malaria parasite Plasmodium malariae (Uganda 1/CDC) reacted strongly with sporozoite antigens of the simian parasite PlAsmodium brasilianum, indicating a shared epitope on sporozoites of the two species. Expand
[20] Distinction of epitopes by monoclonal antibodies
Publisher Summary This chapter discusses the distinction of epitopes by monoclonal antibodies. The chapter explains that hybridoma technology has become very efficient in the production of largeExpand
Antibody-induced ultrastructural changes of malarial sporozoites.
The present study was undertaken to characterize the ultrastructural aspects of antibody-sporozoite interaction and found that antibodies neutralize sporozoites, and cause the formation of a thread-like precipitate on the parasites. Expand
Mokc. Biochem. Parasitol
  • J. Immunol
  • 1976