Protective Microglia and Their Regulation in Parkinson’s Disease

@inproceedings{Le2016ProtectiveMA,
  title={Protective Microglia and Their Regulation in Parkinson’s Disease},
  author={Weidong Le and Junjiao Wu and Yu Jie Tang},
  booktitle={Front. Mol. Neurosci.},
  year={2016}
}
Microglia-mediated neuroinflammation is a hallmark of Parkinson's disease (PD). In the brains of patients with PD, microglia have both neurotoxic and neuroprotective effects, depending on their activation state. In this review, we focus on recent research demonstrating the neuroprotective role of microglia in PD. Accumulating evidence indicates that the protective mechanisms of microglia may result from their regulation of transrepression pathways via nuclear receptors, anti-inflammatory… CONTINUE READING
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