Protective Immunity produced by the Injection of X-irradiated Sporozoites of Plasmodium berghei

@article{Nussenzweig1967ProtectiveIP,
  title={Protective Immunity produced by the Injection of X-irradiated Sporozoites of Plasmodium berghei},
  author={Ruth Sonntag Nussenzweig and Jerome P. Vanderberg and Harry Most and C Orton},
  journal={Nature},
  year={1967},
  volume={216},
  pages={160-162}
}
STUDIES with avian malaria have shown that killed sporozoites as well as sporozoites inactivated with ultraviolet light can produce a partial immunity after injection into birds1,2. On the other hand, attempts to use the erythrocytic stages of the parasite as the source of antigen have met with only limited success with avian3, rodent4 and monkey malaria5,6. Previous attempts to use killed sporozoites of the rodent malarial parasite, Plasmodium berghei, to immunize rodents have been… Expand
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Sporozoites and erythrocytic forms of Plasmodium gallinaceum which had been treated by four different methods were used as antigens to immunize fowls against malaria. Expand
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Intramuscular injection of the killed parasites and the adjuvant conferred a strong immunity against a challenge infection and much of the additional globulin was thought to be non-specific and/or non-protective. Expand
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