Protective Immunity produced by the Injection of X-irradiated Sporozoites of Plasmodium berghei

  title={Protective Immunity produced by the Injection of X-irradiated Sporozoites of Plasmodium berghei},
  author={Ruth Sonntag Nussenzweig and Jerome P. Vanderberg and Harry Most and C Orton},
STUDIES with avian malaria have shown that killed sporozoites as well as sporozoites inactivated with ultraviolet light can produce a partial immunity after injection into birds1,2. On the other hand, attempts to use the erythrocytic stages of the parasite as the source of antigen have met with only limited success with avian3, rodent4 and monkey malaria5,6. Previous attempts to use killed sporozoites of the rodent malarial parasite, Plasmodium berghei, to immunize rodents have been… 

Immunization of monkeys against Plasmodium cynomolgi by X-irradiated sporozoites.

It is indicated that immunization with sporozoites of one species may confer varying degrees of immunity to challenge with other species of rodent malaria.

Local Immune Response to Injection of Plasmodium Sporozoites into the Skin

The studies delineate the early and local response to sporozoite injection into the skin, and suggest that WTS and RAS prime the host immune system in a similar fashion.

Chemical Attenuation of Plasmodium berghei Sporozoites Induces Sterile Immunity in Mice

It is shown that treatment of Plasmodium berghei sporozoites with centanamycin impaired parasite function both in vitro and in vivo, and treated parasites showed arrested liver stage development.

Whole-Sporozoite Malaria Vaccines

A historical perspective is provided and major advances in the development of wholesporozoite malaria vaccines are discussed, as well as the search for immune mechanisms and correlates of protection.

Genetic control of immunity to Plasmodium yoelii sporozoites.

Using a rodent malaria system, it is shown that protective immunity to the preerythrocytic stages of malaria is genetically controlled by MHC and non-MHC genes, and each mechanism is further controlled by H-2-linked Ir genes.

Strain‐specific immunity induced by immunization with pre‐erythrocytic stages of Plasmodium chabaudi

It is shown that the immunity induced by infection with the pre‐erythrocytic stages of these parasites, achieved via inoculation of sporozoites contemporaneously with mefloquine, also has a strain‐specific component.

Intradermal immunization of mice with radiation-attenuated sporozoites of Plasmodium yoelii induces effective protective immunity

The use of a sub-microlitre syringe for intradermal injections yielded excellent protective immunity and it remains to be determined whether an adjuvant treatment can be found to substantially reduce the numbers of attenuated sporozoites required to achieve a strong protective immunity with as few doses as possible for possible extension to immunization of humans.



Active Immunization of Chicks against Plasmodium gallinaceum by Inactivated Homologous Sporozoites and Erythrocytic Parasites

Sporozoites and erythrocytic forms of Plasmodium gallinaceum which had been treated by four different methods were used as antigens to immunize fowls against malaria.


When ducks are injected with formalin-inactivated P. lophurae in combination with a lanolin-like substance, paraffin oil and killed tubercle bacilli, they develop considerable resistance to