Protective Effects of a Culture Supernatant of Lactobacillus acidophilus and Antioxidants on Ileal Ulcer Formation in Rats Treated with a Nonsteroidal Antiinflammatory Drug

@article{Bing1998ProtectiveEO,
  title={Protective Effects of a Culture Supernatant of Lactobacillus acidophilus and Antioxidants on Ileal Ulcer Formation in Rats Treated with a Nonsteroidal Antiinflammatory Drug},
  author={S Bing and Takemi Kinouchi and Keiko Kataoka and Tomomi Kuwahara and Yoshinari Ohnishi},
  journal={Microbiology and Immunology},
  year={1998},
  volume={42}
}
Ileal ulcers and thiobarbituric acid (TBA)‐reactive substances in the ileal mucosa were induced in rats treated with a nonsteroidal antiinflammatory drug, 5‐bromo‐2‐(4‐fluorophenyl)‐3‐(4‐methylsulfonylphenyl)thiophene (BFMeT), at a dose of 1,000 mg/kg administered with tap water as drinking water. However, the formation of ileal ulcers and TBA‐reactive substances in the ileal mucosa was repressed by giving the animals a culture supernatant of Lactobacillus acidophilus as drinking water. We… 

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