Corpus ID: 29699634

Protective Effects of Vitamin E on Methotrexate-Induced Jejunal Mucosal Damage in Rats.

  title={Protective Effects of Vitamin E on Methotrexate-Induced Jejunal Mucosal Damage in Rats.},
  author={B. Burcu and M. Kanter and Z. Orhon and O. Yarali and R. Karabacak},
  journal={Analytical and quantitative cytopathology and histopathology},
  volume={38 2},
  • B. Burcu, M. Kanter, +2 authors R. Karabacak
  • Published 2016
  • Medicine
  • Analytical and quantitative cytopathology and histopathology
  • OBJECTIVE To investigate the possible protective effects of Vitamin E (Vit E) on oxidative stress and jejunal damage in the rat intestinal mucosa after methotrexate (MTX)-induced enterotoxicity. STUDY DESIGN Rats were divided into 3 groups: control, MTX, and MTX+ Vit E; each group contained 8 animals. The control group was given physiological serum in addition to sunflower oil for 3 days. The second group was given sunflower oil with intragastric tube daily, followed by MTX injection (20 mg… CONTINUE READING
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