Protective Effects of Pseudoginsenoside‐F11 on Scopolamine‐induced Memory Impairment in Mice and Rats

@article{Li1999ProtectiveEO,
  title={Protective Effects of Pseudoginsenoside‐F11 on Scopolamine‐induced Memory Impairment in Mice and Rats},
  author={Zhaokui Li and Y. Guo and C F Wu and Xia Li and Jianhong Wang},
  journal={Journal of Pharmacy and Pharmacology},
  year={1999},
  volume={51}
}
  • Z. Li, Y. Guo, +2 authors J. Wang
  • Published 1 April 1999
  • Medicine
  • Journal of Pharmacy and Pharmacology
This study assessed the effects of pseudoginsenoside‐F11, a component of Panax quinquefolium L., on scopolamine‐impaired memory performance in mice and rats. 
Anti-amnesic effect of pseudoginsenoside-F11 in two mouse models of Alzheimer's disease
TLDR
It was found that oral treatment with PF11 significantly mitigated learning and memory impairment in mice given Aβ1-42-treated mice and indicated that PF11 may serve as a potential therapeutic agent for the treatment of AD.
Protective effects of pseudoginsenoside-F11 on methamphetamine-induced neurotoxicity in mice
TLDR
It is demonstrated that pseudoginsenoside-F(11) is effective in protection of MA-induced neurotoxicity and also suggest that natural products, such as ginseng, might be potential candidates for the prevention and treatment of the neurological disorders induced by MA abuse.
Neuroprotective Effect of Pseudoginsenoside-F11 on a Rat Model of Parkinson's Disease Induced by 6-Hydroxydopamine
TLDR
Pseudoginsenoside-F11 has potent anti-Parkinson property possibly through inhibiting free radical formation and stimulating endogenous antioxidant release, as proposed in a rat PD model.
Antagonistic Effect of Pseudoginsenoside-F11 on the Behavioral Actions of Morphine in Mice
TLDR
The antagonistic effect of pseudoginoside-F11 (PF(11)) on the various actions of morphine was studied in mice and it was demonstrated for the first time that PF(11) can antagonize some activities of morphine.
Pseudoginsenoside-F11 ameliorates okadiac acid-induced learning and memory impairment in rats via modulating protein phosphatase 2A
TLDR
The present data indicate that PF11 can ameliorate OA-induced learning and memory impairment in rats via modulating PP2A.
Pseudoginsenoside-F11 attenuates cognitive dysfunction and tau phosphorylation in sporadic Alzheimer's disease rat model.
TLDR
PF11 treatment markedly reduced the neuronal loss, protected the synapse structure, and modulated STZ-induced expression of tau phosphorylation by regulating the insulin signaling pathway and calpain I/CDK5 signaling pathway in the hippocampus.
Pseudoginsenoside-F11 inhibits methamphetamine-induced behaviors by regulating dopaminergic and GABAergic neurons in the nucleus accumbens
TLDR
The present data suggest that Pseudoginsenoside-F11 inhibits METH-induced hyperlocomotion, preference, and accumbal extracellular DA increase by regulating GABAergic neurons and μ-opioid receptors.
Modulation of nitrergic signalling pathway by American ginseng attenuates chronic unpredictable stress-induced cognitive impairment, neuroinflammation, and biochemical alterations
  • P. Rinwa, Anil Kumar
  • Chemistry, Medicine
    Naunyn-Schmiedeberg's Archives of Pharmacology
  • 2013
TLDR
The findings suggest that modulation of nitrergic signalling cascade is involved in the protective effects of AG against CUS-induced cognitive dysfunction, oxidative stress, and neuroinflammation.
Ginseng derivative ocotillol enhances neuronal activity through increased glutamate release: a possible mechanism underlying increased spontaneous locomotor activity of mice
TLDR
The results suggest that ocotillol-evoked neuronal excitability was mediated by increased release of glutamate, which may be responsible for the increased spontaneous locomotor activities of mice in vivo.
Anxiolytic effect of saponins from Panax quinquefolium in mice.
TLDR
The present findings suggest that PQS might be a potential candidate for use as an anxiolytic drug.
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TLDR
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