Protective Effects of Polygonum viviparum L. Root and its Extracts Against Lipid-peroxidation Induced by Indomethacin in Rats

  title={Protective Effects of Polygonum viviparum L. Root and its Extracts Against Lipid-peroxidation Induced by Indomethacin in Rats},
  author={Rifat-uz-Zaman and Muhammad Shoaib Akhtar and Muhammad Shafiq Khan},
  journal={International Journal of Pharmacology},
Anti-Ulcer Effect of Methanol Extract of the Root Bark of EntandrophragmaAngolense ( Meliacaea
as acclaimed by herbalists was studied. The b.w.) using indomethacin and sults revealed that ME exhibited a non significant (p>0.05) dose -ulcer effect against both ulcer-induction models, comparedExpand
Evaluation of antioxidant potential and HPLC based identification of phenolics in Polygonum amplexicaule extract and its fractions.
This study suggested that Polygonum amplexicaule have high content of antioxidants, which needs to be investigated further for their medicinal and/cosmaceutical applications. Expand
Ulcer Effect of Methanol Extract of the Root Bark EntandrophragmaAngolense (Meliacaea ) in Rodents
The anti ulcer activity of methanol extract (ME) of the root bark of Entandrophragmaangolense, as acclaimed by herbalists was studied. The ME obtained by soxhlet extraction was subjected to antiExpand
Polygonum viviparum L. induces vasorelaxation in the rat thoracic aorta via activation of nitric oxide synthase in endothelial cells
The results suggest that PV possesses vasorelaxing action in an endothelium-dependent manner and works through activating Ca2+/calmodulin- dependent NO synthesis; when NO is released and then transferred to smooth muscle cells, NO activates guanylyl cyclase and increases cGMP formation, ultimately resulting in vasore laxation. Expand
Anti-ulcerogenic mechanism of magnesium in indomethacin induced gastric ulcer in rats.
  • E. Adewoye, A. Salami
  • Medicine
  • Nigerian journal of physiological sciences : official publication of the Physiological Society of Nigeria
  • 2013
This study shows that magnesium possesses anti-ulcerogenic properties due to its ability to reduce the number of parietal cell and increase mucous cell counts. Expand
Polygonum viviparum L. inhibits the lipopolysaccharide-induced inflammatory response in RAW264.7 macrophages through haem oxygenase-1 induction and activation of the Nrf2 pathway.
The results suggest that PV possesses anti-inflammatory actions in macrophages and works through a novel mechanism involving Nrf2 actions and HO-1, which could be considered for application as a potential therapeutic approach for inflammation-associated disorders. Expand


Barriers to sexual reproduction in Polygonum viviparum: a comparative developmental analysis of P. viviparum and P. bistortoides.
The virtual absence of sexual reproduction in P. viviparum appears to be due largely to a low rate of fertilization and to embryo/fruit abortion, which contributes to differences in seed production between the two species. Expand
Role of endogenous prostacyclin in gastric ulcerogenic and healing responses—a study using IP-receptor knockout mice
It is suggested that endogenous PGI(2) is involved in the gastric ulcerogenic response to stress, but not in the healing of pre-existing gastric Ulcer ulcers. Expand
Stamen dimorphism in Rhododendron ferrugineum (Ericaceae): development and function.
Stamen dimorphism in the breeding system of the alpine shrub Rhododendron ferrugineum was studied, suggesting that long-level stamens are not responsible for selfing in the absence of pollinators and that reproductive assurance is promoted by short-levelStamens. Expand
Stimulated release of arachidonic acid from rat liver cells by celecoxib and indomethacin.
  • L. Levine
  • Chemistry, Medicine
  • Prostaglandins, leukotrienes, and essential fatty acids
  • 2001
The selective cyclooxygenase-2 (COX) inhibitor, celecoxib, and the non-selective COX-1 and COX-2 inhibitor, indomethacin, at microM concentrations, stimulate the release of arachidonic acid from ratExpand
Developmental analysis of the evolutionary origin of vegetative propagules in Mimulus gemmiparus (Scrophulariaceae).
Mimulus gemmiparus (Scrophulariaceae), a rare endemic of Colorado, has a novel life history that depends on an unusual method of vegetative reproduction. The plants are functionally annuals; however,Expand
Cistifolin, an integrin-dependent cell adhesion blocker from the anti-rheumatic herbal drug, gravel root (rhizome of Eupatorium purpureum).
Compound 1 administered orally two hours before induction of inflammation (in rat paw) by carrageenan inhibited oedema formation in a dose-dependent manner and it appears that 1 has therapeutic potential for diseases where integrin adhesion molecules play a significant role. Expand
Cytotoxic sesquiterpene lactones from Inula britannica.
Cytotoxicity-guided fractionation of the flowers of Inula britannica led to the isolation of four sesquiterpene lactones that showed cytotoxicity against human tumor cell lines. Expand
Pharmacological analysis of cyclooxygenase-1 in inflammation.
  • C. Smith, Y. Zhang, +7 authors P. Isakson
  • Chemistry, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 1998
The results suggest that, in addition to the role of peripherally produced PGs, there is a critical, centrally mediated neurological component to inflammatory pain that is mediated at least in part by COX-2. Expand