Protective Effects of Polygonum viviparum L. Root and its Extracts Against Lipid-peroxidation Induced by Indomethacin in Rats

@article{RifatuzZaman2005ProtectiveEO,
  title={Protective Effects of Polygonum viviparum L. Root and its Extracts Against Lipid-peroxidation Induced by Indomethacin in Rats},
  author={Rifat-uz-Zaman and M. Akhtar and M. Khan},
  journal={International Journal of Pharmacology},
  year={2005},
  volume={1},
  pages={324-328}
}
Anti-Ulcer Effect of Methanol Extract of the Root Bark of EntandrophragmaAngolense ( Meliacaea
as acclaimed by herbalists was studied. The b.w.) using indomethacin and sults revealed that ME exhibited a non significant (p>0.05) dose -ulcer effect against both ulcer-induction models, comparedExpand
Evaluation of antioxidant potential and HPLC based identification of phenolics in Polygonum amplexicaule extract and its fractions.
TLDR
This study suggested that Polygonum amplexicaule have high content of antioxidants, which needs to be investigated further for their medicinal and/cosmaceutical applications. Expand
Ulcer Effect of Methanol Extract of the Root Bark EntandrophragmaAngolense (Meliacaea ) in Rodents
The anti ulcer activity of methanol extract (ME) of the root bark of Entandrophragmaangolense, as acclaimed by herbalists was studied. The ME obtained by soxhlet extraction was subjected to antiExpand
Polygonum viviparum L. induces vasorelaxation in the rat thoracic aorta via activation of nitric oxide synthase in endothelial cells
TLDR
The results suggest that PV possesses vasorelaxing action in an endothelium-dependent manner and works through activating Ca2+/calmodulin- dependent NO synthesis; when NO is released and then transferred to smooth muscle cells, NO activates guanylyl cyclase and increases cGMP formation, ultimately resulting in vasore laxation. Expand
Anti-ulcerogenic mechanism of magnesium in indomethacin induced gastric ulcer in rats.
  • E. Adewoye, A. Salami
  • Medicine
  • Nigerian journal of physiological sciences : official publication of the Physiological Society of Nigeria
  • 2013
TLDR
This study shows that magnesium possesses anti-ulcerogenic properties due to its ability to reduce the number of parietal cell and increase mucous cell counts. Expand
Polygonum viviparum L. inhibits the lipopolysaccharide-induced inflammatory response in RAW264.7 macrophages through haem oxygenase-1 induction and activation of the Nrf2 pathway.
TLDR
The results suggest that PV possesses anti-inflammatory actions in macrophages and works through a novel mechanism involving Nrf2 actions and HO-1, which could be considered for application as a potential therapeutic approach for inflammation-associated disorders. Expand

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