Protective Effects of Nafamostat Mesilate on Liver Injury Induced by Lipopolysaccharide in Rats: Possible Involvement of CD14 and TLR-4 Downregulation on Kupffer Cells

@article{Miyaso2006ProtectiveEO,
  title={Protective Effects of Nafamostat Mesilate on Liver Injury Induced by Lipopolysaccharide in Rats: Possible Involvement of CD14 and TLR-4 Downregulation on Kupffer Cells},
  author={Hideaki Miyaso and Yoshinori Morimoto and M. Ozaki and Sanae Haga and Susumu Shinoura and Yasuhiro Choda and Hiroshi Murata and Goutaro Katsuno and Kamul Huda and Hideo Takahashi and Noriaki Tanaka and Hiromi Iwagaki},
  journal={Digestive Diseases and Sciences},
  year={2006},
  volume={51},
  pages={2007-2012}
}
Nafamostat mesilate (NM) is a synthetic protease inhibitor with various biological effects. To determine its effect on liver injury related to sepsis, we investigated the effects of NM on lipopolysaccharide (LPS)-induced liver injury. Wistar rats were allocated into two groups; the NM group underwent intraperitoneal NM administration 30 min before LPS administration, and the control group underwent PBS administration. Serum AST and ALT levels were significantly decreased in NM-treated rats… CONTINUE READING
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