Protective Effects of Garlic Extract, PMK-S005, Against Nonsteroidal Anti-inflammatory Drugs–Induced Acute Gastric Damage in Rats

@article{Choi2014ProtectiveEO,
  title={Protective Effects of Garlic Extract, PMK-S005, Against Nonsteroidal Anti-inflammatory Drugs–Induced Acute Gastric Damage in Rats},
  author={Yoon Jeong Choi and Nayoung Kim and Ju Yup Lee and Ryoung Hee Nam and Hyun Kyong Hannah Chang and Ji Hyung Seo and Kyu Keun Kang and Hee Jin Kim and Yun Jin Choi and Hye Seung Lee and Dong Ho Lee},
  journal={Digestive Diseases and Sciences},
  year={2014},
  volume={59},
  pages={2927-2934}
}
PMK-S005 is synthetic s-allyl-l-cysteine (SAC), a sulfur-containing amino acid, which was initially isolated from garlic. The antioxidant and anti-inflammation activities of SAC have been demonstrated in diverse experimental animal models. The purpose of this study was to investigate the gastroprotective effects of PMK-S005 against NSAIDs-induced acute gastric damage in rats. Eight-week SD rats were pretreated with PMK-S005 (1, 5, or 10 mg/kg) or rebamipide (50 mg/kg) 1 h before administration… CONTINUE READING
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