Protective Effects of Dietary Carotenoids on Risk of Hip Fracture in Men: The Singapore Chinese Health Study

  title={Protective Effects of Dietary Carotenoids on Risk of Hip Fracture in Men: The Singapore Chinese Health Study},
  author={Zhaoli Dai and Renwei Wang and Li Wei Ang and Yen Ling Low and Jian-Min Yuan and Woon-Puay Koh},
  journal={Journal of Bone and Mineral Research},
Experimental and epidemiologic data suggest that carotenoids in vegetables and fruits may benefit bone health due to their antioxidant properties. The relationship between dietary total and specific carotenoids, as well as vegetables and fruits, and risk of hip fracture was examined among Chinese in Singapore. We used data from the Singapore Chinese Health Study, a prospective cohort of 63,257 men and women who were of ages 45 to 74 years between 1993 and 1998. At recruitment, subjects were… 

Fruit and Vegetable Intake and Risk of Hip Fracture: A Cohort Study of Swedish Men and Women

It is concluded that there is a dose‐response association between fruit and vegetable intake and hip fracture such that an intake below the recommended five servings/day confers higher rates of hip fracture.

Adherence to a vegetable-fruit-soy dietary pattern or the Alternative Healthy Eating Index is associated with lower hip fracture risk among Singapore Chinese.

An Asian diet rich in plant-based foods, namely vegetables, fruit, and legumes such as soy, may reduce the risk of hip fracture.

Greater Intake of Fruit and Vegetables Is Associated with Greater Bone Mineral Density and Lower Osteoporosis Risk in Middle-Aged and Elderly Adults

Greater intake of FV was independently associated with a higher BMD and a lower presence of osteoporosis in middle-aged and elderly Chinese subjects with lower BMI.

Carotenoid dietary intakes and plasma concentrations are associated with heel bone ultrasound attenuation and osteoporotic fracture risk in the European Prospective Investigation into Cancer and Nutrition (EPIC)-Norfolk cohort

Novel evidence is provided that dietary carotenoid intake is relevant to bone health in men and women, demonstrating that associations with bone density status and fracture risk exist for dietary intake of specific carOTenoids and their plasma concentrations.

Carotenoids and risk of fracture: a meta-analysis of observational studies

The hypothesis that higher dietary total carotenoids or β-carotene intake might be potentially associated with a low risk of hip fracture is supported, however, future well-designed prospective cohort studies and randomized controlled trials are warranted to specify the associations between carotanoids and fracture.

Fruit and Vegetable Intake and Hip Fracture Incidence in Older Men and Women: The CHANCES Project

  • V. BenetouP. Orfanos A. Trichopoulou
  • Medicine
    Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
  • 2016
It was concluded that a daily intake of 1 or <1 servings of fruits and vegetables was associated with increased hip fracture risk in relation to moderate daily intakes, and older adults with such low fruit and vegetable consumption may benefit from raising their intakes to moderate amounts in order to reduce their hip fractures.

Vegetable and Fruit Intake and Fracture-Related Hospitalisations: A Prospective Study of Older Women

Increasing vegetable intake, with an emphasis on cruciferous and allium vegetables, may prevent fractures in older postmenopausal women.

Association of dietary fiber and risk of hip fracture in men from the Framingham Osteoporosis Study and the Concord Health and Ageing in Men Project

Dietary fiber was not associated with risk of incident hip fractures in men, and associations within each cohort between fiber intake and risk of hip fractures were not found.



Dietary B vitamin intake and risk of hip fracture: the Singapore Chinese Health Study

SummaryThis prospective cohort study that comprehensively examined effects of different B vitamins in an Asian population showed an inverse relationship between dietary intake of pyridoxine and hip

Protective Effect of Total Carotenoid and Lycopene Intake on the Risk of Hip Fracture: A 17‐Year Follow‐Up From the Framingham Osteoporosis Study

A protective role of several carotenoids for bone health in older adults is suggested and no significant associations were observed with α‐carotene, β‐cryptoxanthin, or lutein + zeaxanthin.

Dietary patterns of antioxidant vitamin and carotenoid intake associated with bone mineral density: findings from post-menopausal Japanese female subjects

The findings suggest the combination of vitamin C and β-cryptoxanthin intakes might provide benefit to bone health in post-menopausal Japanese female subjects.

Gender-specific associations between soy and risk of hip fracture in the Singapore Chinese Health Study.

There was a statistically significant association of tofu equivalents, soy protein, and isoflavones with hip fracture risk among women but not among men, and risk levels were comparable across the second, third, and fourth quartiles of soy intake categories.

Bone mineral density in post-menopausal female subjects is associated with serum antioxidant carotenoids

The findings suggest that β-cryptoxanthin and β-carotene might provide benefits to bone health in post-menopausal female subjects, andAntioxidant carotenoids, especially β- cryptoxanth in particular, significantly but partly associate with the radial BMD in post -menopausalFemale subjects.

Inverse association of carotenoid intakes with 4-y change in bone mineral density in elderly men and women: the Framingham Osteoporosis Study.

Carotenoids showed protective associations against 4-y loss in trochanter BMD in men and in lumbar spine in women, and although not consistent across all BMD sites examined, these results support a protective role of carotenoid for B MD in older men and women.

Protective effect of total and supplemental vitamin C intake on the risk of hip fracture—a 17-year follow-up from the Framingham Osteoporosis Study

In the Framingham Study, subjects with higher total or supplemental vitamin C intake had fewer hip fractures and non-vertebral fractures as compared to subjects with lower intakes, suggesting a possible protective effect of vitamin C on bone health in older adults.

Serum carotenoid concentrations in postmenopausal women from the United States with and without osteoporosis.

Investigation of the interrelationships among serum carotenoid concentrations, fruit and vegetable intake, and osteoporosis in postmenopausal women foundCarotenoids that may have beneficial skeletal effects are lower in women with osteoporeosis.

Potassium, magnesium, and fruit and vegetable intakes are associated with greater bone mineral density in elderly men and women.

The hypothesis that alkaline-producing dietary components, specifically, potassium, magnesium, and fruit and vegetables, contribute to maintenance of BMD is supported.

Fruit and vegetable intakes and bone mineral status: a cross sectional study in 5 age and sex cohorts.

Higher fruit and vegetable intakes may have positive effects on bone mineral status in both younger and older age groups, especially at the spine and femoral neck.