Protective Effects of Berberine in an Experimental Rat Osteoarthritis Model

@article{Hu2011ProtectiveEO,
  title={Protective Effects of Berberine in an Experimental Rat Osteoarthritis Model},
  author={Pengfei Hu and Wei-ping Chen and Jing-li Tang and Jia-peng Bao and Li-Dong Wu},
  journal={Phytotherapy Research},
  year={2011},
  volume={25}
}
Berberine shows anticancer, antibacterial, antiinflammatory and antioxidant effects and may be useful in many clinical applications. The effects of berberine on articular cartilage metabolism remain unknown, so this study was performed to evaluate these effects in vitro and in vivo. For the in vitro work, rat articular chondrocytes were cultured in a monolayer and matrix metalloproteinase‐1 (MMP‐1), ‐3, ‐13 and tissue inhibitor of metalloproteinase (TIMP‐1) expression was evaluated by real‐time… Expand
Berberine inhibits the interleukin‐1 beta‐induced inflammatory response via MAPK downregulation in rat articular chondrocytes
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Berberine prevents human nucleus pulposus cells from IL-1β-induced extracellular matrix degradation and apoptosis by inhibiting the NF-κB pathway
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