Protective Effects of Alpha-Lipoic Acid on Methotrexate-Induced Oxidative Lung Injury in Rats

  title={Protective Effects of Alpha-Lipoic Acid on Methotrexate-Induced Oxidative Lung Injury in Rats},
  author={Huseyin Arpag and Mehmet G{\"u}l and Yusuf Aydemir and Nurhan Atilla and Birgul Yigitcan and Tuğrul Çakır and Cemal Polat and {\"O}zer Þehirli and Muhammet Sayan},
  journal={Journal of Investigative Surgery},
  pages={107 - 113}
ABSTRACT Objective: Oxidative stress is one of the major causes of methotrexate induced lung injury (MILI). Alpha-lipoic acid (ALA), which occurs naturally in human food, has antioxidative and anti-inflammatory activities. The aim of this study was to research the potential protective role of ALA on MILI in rats. Methods: Twenty one rats were randomly subdivided into three groups: control (group I), methotrexate (MTX) treated (group II), and MTX+ALA treated (group III). Lung injury was… 

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