Protective Effects of Alpha-Lipoic Acid on Methotrexate-Induced Oxidative Lung Injury in Rats

  title={Protective Effects of Alpha-Lipoic Acid on Methotrexate-Induced Oxidative Lung Injury in Rats},
  author={Huseyin Arpag and Mehmet G{\"u}l and Yusuf Aydemir and Nurhan Atilla and Birgul Yigitcan and Tuğrul Çakır and Cemal Polat and {\"O}zer Þehirli and Muhammet Sayan},
  journal={Journal of Investigative Surgery},
  pages={107 - 113}
ABSTRACT Objective: Oxidative stress is one of the major causes of methotrexate induced lung injury (MILI). Alpha-lipoic acid (ALA), which occurs naturally in human food, has antioxidative and anti-inflammatory activities. The aim of this study was to research the potential protective role of ALA on MILI in rats. Methods: Twenty one rats were randomly subdivided into three groups: control (group I), methotrexate (MTX) treated (group II), and MTX+ALA treated (group III). Lung injury was… Expand
9 Citations
Ameliorating Effect of Alpha-lipoic Acid on Methotrexate-induced Histological and Biochemical Changes in The Lung of Adult Albino Rat
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The impact of Keap1/Nrf2, P38MAPK/NF-κB and Bax/Bcl2/caspase-3 signaling pathways in the protective effects of berberine against methotrexate-induced nephrotoxicity.
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Reduced folate carrier‐mediated methotrexate transport in human distal lung epithelial NCl‐H441 cells
Examination of MTX uptake in NCl‐H441 (H441) cells, another in vitro alveolar epithelial model, focusing on the localization of RFC is examined, finding that reduced folate carrier is mainly involved in an influx of transport of methotrexate. Expand


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Melatonin prevents methotrexate‐induced hepatorenal oxidative injury in rats
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Protective effects of erythropoietin and N-acetylcysteine on methotrexate-induced lung injury in rats.
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The Protective Effect of Alpha-Lipoic Acid in Lipopolysaccharide-Induced Acute Lung Injury Is Mediated by Heme Oxygenase-1
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Oxidative stress contributes to methotrexate-induced small intestinal toxicity in rats
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Effects of N-acetylcysteine on methotrexate-induced small intestinal damage in rats.
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Anti-Oxidative Effect of Lipoic Acid in Spinal Cord Ischemia/Reperfusion
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