Protective Effects of Alpha-Lipoic Acid on Methotrexate-Induced Oxidative Lung Injury in Rats

@article{Arpag2018ProtectiveEO,
  title={Protective Effects of Alpha-Lipoic Acid on Methotrexate-Induced Oxidative Lung Injury in Rats},
  author={Huseyin Arpag and Mehmet G{\"u}l and Yusuf Aydemir and Nurhan Atilla and Birgul Yigitcan and Tuğrul Çakır and Cemal Polat and {\"O}zer Þehirli and Muhammet Sayan},
  journal={Journal of Investigative Surgery},
  year={2018},
  volume={31},
  pages={107 - 113}
}
ABSTRACT Objective: Oxidative stress is one of the major causes of methotrexate induced lung injury (MILI). Alpha-lipoic acid (ALA), which occurs naturally in human food, has antioxidative and anti-inflammatory activities. The aim of this study was to research the potential protective role of ALA on MILI in rats. Methods: Twenty one rats were randomly subdivided into three groups: control (group I), methotrexate (MTX) treated (group II), and MTX+ALA treated (group III). Lung injury was… 
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22 Citations

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47 References

Protective effects of alpha-lipoic Acid on oleic Acid-induced acute lung injury in rats.

BACKGROUND Oxidative stress is believed to be an important factor in the pathogenesis of acute lung injury (ALI). AIMS The aim of this study was to investigate the possible protective role of…

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Protective effects of erythropoietin and N-acetylcysteine on methotrexate-induced lung injury in rats.

EPO and NAC have significant preventive effects on MTX-induced lung injury in rats and decreased antioxidant capacity and increased MDA level may cause the oxidative damage in MTX group.

The Protective Effect of Alpha-Lipoic Acid in Lipopolysaccharide-Induced Acute Lung Injury Is Mediated by Heme Oxygenase-1

The results suggest that the protection mechanism of ALA may be through HO-1 induction and in turn suppressing NF-κB-mediated inflammatory responses.

Oxidative stress contributes to methotrexate-induced small intestinal toxicity in rats

It is suggested that oxidative stress plays an important role in the MTX-induced small intestinal damage, especially neutrophil infiltration, and the modulation of oxidative stress would be useful in reducing intestinal damage in MTX treatment.

Effects of N-acetylcysteine on methotrexate-induced small intestinal damage in rats.

Administration of N-acetylcysteine provides protection against the MTX-induced damage to small intestinal epithelium in rats, and this protective effect of NAC may have clinical applications in chemotherapy.

Molecular Mechanisms of Lipoic Acid Protection against Aflatoxin B1-Induced Liver Oxidative Damage and Inflammatory Responses in Broilers

Results indicate that α-LA may be effective in preventing hepatic oxidative stress, down-regulating the expression of hepatic pro-inflammatory cytokines, as well as inhibiting NF-κB expression.

Alpha-lipoic acid attenuates lipopolysaccharide-induced kidney injury

LA treatment attenuates LPS-induced kidney injury, such as renal tubular dysfunction, by suppression of apoptosis, and inflammation, by attenuated by LA pretreatment.

Protective Effect of Alpha Lipoic Acid on Rat Sciatic Nerve Ischemia Reperfusion Damage.

Increased fibronectin observed after ischemia/reperfusion of rat sciatic nerve is reduced after the administration of ALA, indicating that the function of fibronsectin, to reconnect cut nerve segments and regenerate nerves, is more prominent than its function in tissue healing after ischemic nerve.

Anti-Oxidative Effect of Lipoic Acid in Spinal Cord Ischemia/Reperfusion

LA pretreatment reduced neurologic injury in the rats, most probably by maintaining the oxidant/anti-oxidant ion balance during spinal cord ischemia during spinal ischemic/reperfusion injury.