Protective Effects of Alpha-Lipoic Acid on Methotrexate-Induced Oxidative Lung Injury in Rats

@article{Arpag2018ProtectiveEO,
  title={Protective Effects of Alpha-Lipoic Acid on Methotrexate-Induced Oxidative Lung Injury in Rats},
  author={Huseyin Arpag and M. G{\"u}l and Y. Aydemir and N. Atilla and B. Yigitcan and T. Çakır and C. Polat and {\"O}zer Þehirli and M. Sayan},
  journal={Journal of Investigative Surgery},
  year={2018},
  volume={31},
  pages={107 - 113}
}
  • Huseyin Arpag, M. Gül, +6 authors M. Sayan
  • Published 2018
  • Medicine
  • Journal of Investigative Surgery
  • ABSTRACT Objective: Oxidative stress is one of the major causes of methotrexate induced lung injury (MILI). Alpha-lipoic acid (ALA), which occurs naturally in human food, has antioxidative and anti-inflammatory activities. The aim of this study was to research the potential protective role of ALA on MILI in rats. Methods: Twenty one rats were randomly subdivided into three groups: control (group I), methotrexate (MTX) treated (group II), and MTX+ALA treated (group III). Lung injury was… CONTINUE READING

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