Protective Effect of Sundarban Honey against Acetaminophen-Induced Acute Hepatonephrotoxicity in Rats

@article{Afroz2014ProtectiveEO,
  title={Protective Effect of Sundarban Honey against Acetaminophen-Induced Acute Hepatonephrotoxicity in Rats},
  author={Rizwana Afroz and E. M. Tanvir and Md Fuad Hossain and Siew Hua Gan and Md. Parvez. and Md. Aminul Islam and Md. Ibrahim Khalil},
  journal={Evidence-based Complementary and Alternative Medicine : eCAM},
  year={2014},
  volume={2014}
}
Honey, a supersaturated natural product of honey bees, contains complex compounds with antioxidant properties and therefore has a wide a range of applications in both traditional and modern medicine. In the present study, the protective effects of Sundarban honey from Bangladesh against acetaminophen- (APAP-) induced hepatotoxicity and nephrotoxicity in experimental rats were investigated. Adult male Wistar rats were pretreated with honey (5 g/kg) for 4 weeks, followed by the induction of… 

Figures and Tables from this paper

Satkara (Citrus macroptera) Fruit Protects against Acetaminophen-Induced Hepatorenal Toxicity in Rats
TLDR
Pretreatment with EECM prior to acetaminophen administration significantly improved all investigated biochemical parameters, that is, transaminase activities, alkaline phosphatase, lactate dehydrogenase, γ-glutamyl transferase activities and total bilirubin, total cholesterol, triglyceride and creatinine, urea, uric acid, sodium, potassium and chloride ions, and TBARS levels.
Nephroprotective potential of Cynara scolymus L. floral extract in cisplatin induced nephrotoxicity in rats
TLDR
The extract attenuated the degenerative and necrotic changes of proximal convoluted tubules induced by cDDP which initiates the good nephroprotective potential of C. scolymus extract.
Ameliorative effects of ethanolic constituents of Bangladeshi propolis against tetracycline-induced hepatic and renal toxicity in rats.
TLDR
The phenolic compounds identified in propolis from Bangladesh were effective against tetracycline-induced hepatic and renal toxicity and may be a promising natural product in reducing the effects of chronic liver and kidney damage.
Therapeutic Implication of Honey against Chronic Carbon Tetrachloride-Induced Liver Injury via Enhancing Antioxidant Potential and Maintenance of Liver Tissue Architecture
TLDR
Honey has a remarkable protective effect against CCl 4 -induced liver toxicity at antioxidant enzyme, histological and protein expression level, and the severity of liver tissue alteration was significantly reduced.
Antioxidant Properties and Dose-Dependent Effects of Monkey Fruits ( Artocarpus lakoocha ) against Paracetamol-Induced Hepato-Renal Toxicity in Rats
TLDR
Overall, AL fruit is an excellent source of natural antioxidants and possess hepatorenal protective activity against paracetamol-induced liver and kidney injuries.
Nephroprotective activity of ethanolic extract of Cinnamomum zeylanicum bark against acetaminophen induced nephrotoxicity in albino rats
TLDR
It was observed that ethanolic extract of Cinnamomum zeylanicum bark has a significant nephroprotective activity against acetaminophen induced nephrotoxicity in albino rats.
Honey attenuates the toxic effects of the low dose of tartrazine in male rats.
TLDR
Honey protects male rats against tartrazine toxicity in an experiment conducted for 8 weeks, and increases antioxidants and high-density lipoproteins, and decreased lipid peroxidation, liver enzyme and kidney parameters.
Sundarban Honey Confers Protection against Isoproterenol-Induced Myocardial Infarction in Wistar Rats
TLDR
Investigation of the cardioprotective effects of Sundarban honey in rats with isoproterenol- (ISO-) induced myocardial infarction indicated that Sundar Ban honey confers protection against ISO-induced oxidative stress in the myocardium, and histopathological findings of the heart tissues confirmed the biochemical findings.
Histopathological Study of Protective Effects of Honey on Subacute Toxicity of Acrylamide-Induced Tissue Lesions in Rats’ Brain and Liver
TLDR
The severity of tissue lesions caused by the ACR can be reduced by honey, likely through its antioxidant activity, and increasing concentrations of honey will enhance its effectiveness.
...
...

References

SHOWING 1-10 OF 58 REFERENCES
Dietary honey and ginseng protect against carbon tetrachloride-induced hepatonephrotoxicity in rats.
Potential protective effect of honey against paracetamol-induced hepatotoxicity.
TLDR
Honey can be used as an effective hepatoprotective agent against paracetamol-induced liver damage and reduced both oxidative stress and inflammatory cytokines.
The Protective Effect of Honey Against Amikacin- induced Nephrotoxicity in Rats
TLDR
Honey decreased nephrotoxicity induced by amikacin through interference with the oxidative stress process, i.e. honey acts as free radical scavenger.
Hepatoprotective Potential of Chestnut Bee Pollen on Carbon Tetrachloride-Induced Hepatic Damages in Rats
TLDR
The findings suggest that chestnut bee pollen can be used as a safe alternative to the silibinin in the treatment of liver injuries and demonstrated that the chestnut pollen protects the hepatocytes from the oxidative stress and promotes the healing of the liver damage induced by CCI4 toxicity.
Hepatoprotective Activity of Aerva lanata Linn. Against Paracetamol Induced Hepatotoxicity in Rats
TLDR
It was concluded from the result that the hydroalcoholic extract of Aerva lanata possesses hepatoprotective activity against paracetamol induced hepatotoxicity in rats.
HEPATOTHERAPEUTIC EFFECTS OF MIKANIA SCANDENS (L.) WILLD. ON PARACETAMOL INDUCED HEPATOTOXICITY IN RATS
TLDR
It can be concluded that the plant Mikania scandens (L.)Willd possesses hepatoprotective activity against paracetamol induced hepatotoxicity in rats.
The protective effect of melatonin on cisplatin nephrotoxicity
TLDR
The present study suggests that melatonin may be of therapeutic benefit when used with CP, and elucidates the role of the antioxidant system in CP‐induced nephrotoxicity and the nephroprotection by melatonin.
Anzer honey prevents N-ethylmaleimide-induced liver damage in rats.
  • Asli Korkmaz, D. Kolankaya
  • Biology
    Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie
  • 2009
Antioxidant effect of vitamin E and selenium on lipid peroxidation, enzyme activities and biochemical parameters in rats exposed to aluminium.
  • F. El-Demerdash
  • Biology, Chemistry
    Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements
  • 2004
Physicochemical and antioxidant properties of Bangladeshi honeys stored for more than one year
TLDR
It is postulated that the low rate of HMF formation could be attributed to the acidic and low moisture content in the samples, and multifloral honeys have higher antioxidant properties based on their high levels of phenolics, flavonoids, AEAC, DPPH and FRAP when compared to monofloral honey.
...
...