Protective Effect of Oestrogens against the Toxic Decomposition Products of Tribromoethanol

@article{Nicol1965ProtectiveEO,
  title={Protective Effect of Oestrogens against the Toxic Decomposition Products of Tribromoethanol},
  author={Thomas Nicol and Barrie Vernon‐roberts and D. C. Quantock},
  journal={Nature},
  year={1965},
  volume={208},
  pages={1098-1099}
}
THE purpose of the present communication is to record that oestrogens have a protective effect against the toxic decomposition products of the anaesthetic tribromoethanol (‘Avertin’). 
View on Springer
ncbi.nlm.nih.gov
14 Citations
Highly Influential Citations
1
Background Citations
5

14 Citations

Teratogenic Activity of Nitrous Oxide

Exposure of pregnant rats to an atmosphere containing nitrous oxide resulted in foetuses with abnormalities of vertebrae and ribs, and in death and resorption of foetuses. The lethal effects seemed…

A cyclodextrin formulation to improve use of the anesthetic tribromoethanol (Avertin®)

The improved solubility of TBE with HP-β-CD and the reduced variability in anesthetic response warrants the further investigation of this formulation, while the value of using the anticholinergic atropine in association with TBE for anesthesia is identified.

An evaluation of preparation methods and storage conditions of tribromoethanol.

The toxicity associated with the lethal TBE in this study appears to be a result of a chemical reaction or breakdown product that has not yet been reported.

Professor Barrie Vernon-Roberts, AO, MD, BSc, PhD, FRCPath, FRCPA, FAOrthA (Hon), FRS.SA

This issue of Inflammopharmacology contains papers that have been submitted to commemorate the life and work of Professor Barrie Vernon-Roberts, an outstanding clinical scientist in the field of bone…

Anesthesia and Analgesia in Rodents

Increased anesthesia time using 2,2,2-tribromoethanol–chloral hydrate with low impact on mouse psychoacoustics

Inflammation and acute myocardial ischemia-reperfusion injury using a closed-chest mouse model

In isolated Langendorff-perfused hearts, IPC resulted in protection of ASC deficient and WT but not of Nlrp3 deficient hearts, suggesting abrogation of IPC through diminished IL-6 signaling.

Peritonitis in Nude Mice in a Xenograft Study.

It is concluded that adequate mixing and storage of tribromoethanol are essential and that it is a safe and effective anesthetic when properly used.

7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES)

The clock, Circadian Rhythms, and Breast Cancer should not be construed as an official Department of the Army position, policy or decision unless so designated by other documentation.

Developing a Mouse Model of Sensory and Cognitive Deficits for Multiple Sclerosis

In this project, a novel mouse model of MS with a focus on cognitive dysfunction and defective myelin is developed using homologous recombination in embryonic stem cells and neurophysiological techniques to assess cognitive deficits are developed.

References

Effect of Œstradiol Benzoate and Orchidectomy on the Toxicity of Trypan Blue

The reticulo-endothelial cells, which specifically store the vital dye, are affected in the same manner, and it is probable that the resulting inhibition of the functional capacity of the reticulum system is partly responsible for the toxic manifestations of trypan blue.