Protective Effect of Glycyrrhizin, a Direct HMGB1 Inhibitor, on Focal Cerebral Ischemia/Reperfusion-Induced Inflammation, Oxidative Stress, and Apoptosis in Rats

@inproceedings{Gong2014ProtectiveEO,
  title={Protective Effect of Glycyrrhizin, a Direct HMGB1 Inhibitor, on Focal Cerebral Ischemia/Reperfusion-Induced Inflammation, Oxidative Stress, and Apoptosis in Rats},
  author={Gu Gong and Lei Xiang and Libang Yuan and Ling Hu and Wei Wu and Lin Cai and Liang Yin and Hailong L. Dong},
  booktitle={PloS one},
  year={2014}
}
AIM Glycyrrhizin (GL) has been reported to protect against ischemia and reperfusion (I/R)-induced injury by inhibiting the cytokine activity of high mobility group box 1 (HMGB1). In the present study, the protective effects of GL against I/R injury, as well as the related molecular mechanisms, were investigated in rat brains. METHODS Focal cerebral I/R injury was induced by intraluminal filamentous occlusion of the middle cerebral artery (MCA) in Male Sprague-Dawley rats. GL alone or GL and… CONTINUE READING

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Glycyrrhizin attenuates ischemic spinal cord injury by suppressing HMGB1 in rats

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